发明授权
US07429616B2 Synthesis and complete stereochemical assignment of psymberin/irciniastatin for use as antitumor compounds
失效
用于抗肿瘤化合物的精氨酸/ irciniastatin的合成和完全立体化学分配
- 专利标题： Synthesis and complete stereochemical assignment of psymberin/irciniastatin for use as antitumor compounds
- 专利标题（中）： 用于抗肿瘤化合物的精氨酸/ irciniastatin的合成和完全立体化学分配
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申请号： US11182069申请日： 2005-07-15
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公开(公告)号： US07429616B2公开(公告)日： 2008-09-30
- 发明人: Jef De Brabander , Xin Jiang
- 申请人： Jef De Brabander , Xin Jiang
- 申请人地址： US TX Austin
- 专利权人： Board of Regents, University of Texas System
- 当前专利权人： Board of Regents, University of Texas System
- 当前专利权人地址： US TX Austin
- 代理机构： Foley & Lardner LLP
- 主分类号： A61K31/35
- IPC分类号： A61K31/35 ; C07D311/02
摘要：
The invention relates to the synthesis and complete stereochemical assignments of cytotoxic compounds such as compound 28-a and its stereoisomers: The invention further provides processes for making the compounds, their synthetic intermediates, and for methods of using the compounds and their pharmaceutical compositions for the treatment of neoplastic diseases.