- 专利标题: Fused cyclic modulators of nuclear hormone receptor function
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申请号: US11168223申请日: 2005-06-28
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公开(公告)号: US07432267B2公开(公告)日: 2008-10-07
- 发明人: Mark E. Salvati , James Aaron Balog , Weifang Shan , Sören Giese , Lalgudi S. Harikrishnan
- 申请人: Mark E. Salvati , James Aaron Balog , Weifang Shan , Sören Giese , Lalgudi S. Harikrishnan
- 申请人地址: US NJ Princeton
- 专利权人: Bristol-Myers Squibb Comapny
- 当前专利权人: Bristol-Myers Squibb Comapny
- 当前专利权人地址: US NJ Princeton
- 代理商 Gary D. Greenblatt; Anastasia P. Winslow
- 主分类号: C07D487/08
- IPC分类号: C07D487/08 ; A61K31/498
摘要:
Disclosed are compounds having the formula (I): including compounds of formulae (Ia) and (Ib): wherein G is an optionally substituted aryl or heterocyclo, L is an optional linker, M is a bond, O, CR7R7′ or NR10, and M′ is a bond or NR10, with the proviso that at least one of M or M′ must be a bond; E is C=Z2, CR7CR7′, SO2, P═OR2, or P═OOR2; Z1 is O, S, NH, or NR6; A1 is CR7 or N; A2 is CR7 or N; Y is J-J′-J″ where J is (CR7R7′)n and n=0−3, J′ is a bond or O, S, S═O, SO2, NH, NR6, C═O, CO═O, NR1C═O, CR7R7′, C═CR8R8′, R2P═O, OPOOR2, OPO2, OSO2, C═N, NHNH, NHNR6, NR6NH, N═N, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo or aryl or substituted aryl, and J″ is (CR7R7′)n and n=0−3; and W, Q, R2, R6, R7, R7′, R8, R8′, R9, R9′, and R10 are as defined in the specification and/or claims herein, to methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and to pharmaceutical compositions containing such compounds.