发明授权
- 专利标题: N-aroyl cyclic amines
- 专利标题(中): N-芳酰基环胺
-
申请号: US10477008申请日: 2002-05-02
-
公开(公告)号: US07432270B2公开(公告)日: 2008-10-07
- 发明人: Clive Leslie Branch , Steven Coulton , Amanda Johns , Christopher Norbert Johnson , Roderick Alan Porter , Geoffrey Stemp , Kevin Thewlis
- 申请人: Clive Leslie Branch , Steven Coulton , Amanda Johns , Christopher Norbert Johnson , Roderick Alan Porter , Geoffrey Stemp , Kevin Thewlis
- 申请人地址: GB Brentford, Middlesex
- 专利权人: SmithKline Beecham p.l.c.
- 当前专利权人: SmithKline Beecham p.l.c.
- 当前专利权人地址: GB Brentford, Middlesex
- 代理商 Kathryn L. Sieburth; Mary E. McCarthy; Charles M. Kinzig
- 优先权: GB0111184.8 20010505; GB0111189.7 20010505; GB0121303.2 20010903; GB0130331.2 20011219; GB0130392.4 20011219
- 国际申请: PCT/GB02/02042 WO 20020502
- 国际公布: WO02/090355 WO 20021114
- 主分类号: A61K31/498
- IPC分类号: A61K31/498 ; C07D403/14 ; C07D405/14 ; C07D409/14 ; C07D417/14
摘要:
This invention relates to N-aroyl cyclic amine derivatives and their use as orexin antagonists wherein: Y represents a bond, oxygen, or a group (CH2)n, wherein n represents 1, 2 or 3; m represents 1, 2, or 3; p represents ) or 1; X is NR, wherein R is H or (C1-4)alkyl; Ar1 is aryl, or a mono or bicyclic heteroaryl group containing up to 3 heteroatoms selected from N, O and S; any of which may be optionally substituted; A2 represents phenyl or a 5- or 6-membered heterocyclyl group containing up to 3 heteroatoms selected from N, O and S, wherein the phenyl or heterocyclyl group is substituted by R1 and further optional substituents; or Ar2 represents an optionally substituted bicyclic aromatic or bicyclic heteroaromatic group containing up to 3 heteroatoms selected from N, O and S; R1 represents hydrogen, optionally substituted (C1-4)alkoxy, halo, cyano, optionally substituted (C1-6)alkyl, optionally substituted phenyl, or an optionally substituted 5- or 6-membered heterocyclyl group containing up to 4 heteroatoms selected from N, O and S; when Ar1 is aryl p is not 1, or a pharmaceutical acceptable salt thereof.
公开/授权文献
- US20040143115A1 N-aroyl cyclic amines 公开/授权日:2004-07-22
信息查询
IPC分类: