Invention Grant
US07432278B2 Dicationic imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines as antiprotozoal agents
有权
二咪唑并[1,2-a]吡啶和5,6,7,8-四氢 - 咪唑并[1,2-a]吡啶作为抗原虫剂
![Dicationic imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines as antiprotozoal agents](/docs/US/2008-10-07/US07432278B2/abs.jpg.600x600.jpg)
- Patent Title: Dicationic imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines as antiprotozoal agents
- Patent Title (中): 二咪唑并[1,2-a]吡啶和5,6,7,8-四氢 - 咪唑并[1,2-a]吡啶作为抗原虫剂
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Application No.: US11074565Application Date: 2005-03-08
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Publication No.: US07432278B2Publication Date: 2008-10-07
- Inventor: David W. Boykin , Richard R. Tidwell , W. David Wilson , Mohamed A. Ismail
- Applicant: David W. Boykin , Richard R. Tidwell , W. David Wilson , Mohamed A. Ismail
- Applicant Address: US NC Chapel Hill US GA Atlanta
- Assignee: The University of North Carolina at Chapel Hill,Georgia State University Research Foundation, Inc.
- Current Assignee: The University of North Carolina at Chapel Hill,Georgia State University Research Foundation, Inc.
- Current Assignee Address: US NC Chapel Hill US GA Atlanta
- Agency: Jenkins, Wilson, Taylor & Hunt, P.A.
- Main IPC: C07D471/02
- IPC: C07D471/02 ; C07D491/02 ; C07D498/02 ; C07D513/02 ; C07D515/02 ; A01N43/42 ; A61K31/44
![Dicationic imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines as antiprotozoal agents](/abs-image/US/2008/10/07/US07432278B2/abs.jpg.150x150.jpg)
Abstract:
A method for treating a microbial infection, including an infection from a protozoan pathogen, such as Trypanosoma brucei rhodesiense and Plasmodium falciparum, in a subject in need thereof by administering to the subject an effective amount of a dicationic imidazopyridine compound or a dicationic tetrahydro-imidazopyridine compound. Processes for synthesizing dicationic imidazopyridines and dicationic tetrahydro-imidazopyridines and the novel dicationic imidazopyridine and dicationic tetrahydro-imidazopyridine compounds themselves.
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