Invention Grant
- Patent Title: Method for producing enantiomer-pure aminoalcohols
- Patent Title (中): 产生对映体纯氨基醇的方法
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Application No.: US10587440Application Date: 2005-01-18
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Publication No.: US07435835B2Publication Date: 2008-10-14
- Inventor: Rainer Stürmer
- Applicant: Rainer Stürmer
- Applicant Address: DE Ludwigshafen
- Assignee: BASF AG
- Current Assignee: BASF AG
- Current Assignee Address: DE Ludwigshafen
- Agency: Connolly Bove Lodge & Hutz LLP
- Priority: DE102004004719 20040129
- International Application: PCT/EP2005/000420 WO 20050118
- International Announcement: WO2005/073215 WO 20050811
- Main IPC: C07D333/18
- IPC: C07D333/18 ; C07D333/24
Abstract:
The invention relates to a process for preparing enantiomerically pure alcohol of the formula 1, which comprises (i) reducing the ketone of the formula 3to the racemic alcohol of the formula 4, (ii) enantioselectively acylating the racemic alcohol of the formula 4 with succinic anhydride in the presence of a lipase to give the succinic semiester of the formula 7, (iii) separating off the succinic semiester of the formula 7 from the unreacted enantiomer of the formula 4, (iv) reacting the enantiomerically pure alcohol of the formula 4 with methylamine to give the enantiomerically pure alcohol of the formula 1.
Public/Granted literature
- US20070128704A1 Method for producing enantiomer-pure aminoalcohols Public/Granted day:2007-06-07
Information query
