Invention Grant
US07442514B2 Mutants of the factor VII-activating protease and detection methods using specific antibodies
有权
因子VII活化蛋白酶的突变体和使用特异性抗体的检测方法
- Patent Title: Mutants of the factor VII-activating protease and detection methods using specific antibodies
- Patent Title (中): 因子VII活化蛋白酶的突变体和使用特异性抗体的检测方法
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Application No.: US10930754Application Date: 2004-09-01
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Publication No.: US07442514B2Publication Date: 2008-10-28
- Inventor: Juergen Roemisch , Hans-Arnold Stoehr , Annette Feussner , Wiegand Lang , Thomas Weimer , Margret Becker , Claudia Nerlich , Gudrun Muth-Naumann , Bernd Knoblauch
- Applicant: Juergen Roemisch , Hans-Arnold Stoehr , Annette Feussner , Wiegand Lang , Thomas Weimer , Margret Becker , Claudia Nerlich , Gudrun Muth-Naumann , Bernd Knoblauch
- Applicant Address: DE Marburg
- Assignee: CSL Behring GmbH
- Current Assignee: CSL Behring GmbH
- Current Assignee Address: DE Marburg
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.
- Priority: DE10036641 20000726; DE10050040 20001010; DE10052319 20001021; DE10118706 20010412
- Main IPC: G01N33/53
- IPC: G01N33/53
Abstract:
Mutants of the DNA sequence coding for the protease (FSAP) which activates blood clotting factor VII and single-chain plasminogen activators, the mutants comprising a G/C base exchange at nucleotide position 1177 and/or a G/A base exchange at nucleotide position 1601, are described. The corresponding protease has a Glu/Gln exchange at amino acid position 393 and/or a Gly/Glu exchange at amino acid position 534. Diagnostic methods which are used for detecting FSAP in body fluids or tissue cells and also for identifying patients with genetic heterozygous or homozygous FSAP expression are also described. In addition, antibodies against FSAP and its mutants are disclosed and diagnostic methods which can be used to detect antibodies against FSAP and its mutants are specified.
Public/Granted literature
- US20050032109A1 Mutants of the factor VII-activating protease and detection methods using specific antibodies Public/Granted day:2005-02-10
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