发明授权
US07442514B2 Mutants of the factor VII-activating protease and detection methods using specific antibodies
有权
因子VII活化蛋白酶的突变体和使用特异性抗体的检测方法
- 专利标题： Mutants of the factor VII-activating protease and detection methods using specific antibodies
- 专利标题（中）： 因子VII活化蛋白酶的突变体和使用特异性抗体的检测方法
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申请号： US10930754申请日： 2004-09-01
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公开(公告)号： US07442514B2公开(公告)日： 2008-10-28
- 发明人: Juergen Roemisch , Hans-Arnold Stoehr , Annette Feussner , Wiegand Lang , Thomas Weimer , Margret Becker , Claudia Nerlich , Gudrun Muth-Naumann , Bernd Knoblauch
- 申请人： Juergen Roemisch , Hans-Arnold Stoehr , Annette Feussner , Wiegand Lang , Thomas Weimer , Margret Becker , Claudia Nerlich , Gudrun Muth-Naumann , Bernd Knoblauch
- 申请人地址： DE Marburg
- 专利权人： CSL Behring GmbH
- 当前专利权人： CSL Behring GmbH
- 当前专利权人地址： DE Marburg
- 代理机构： Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.
- 优先权： DE10036641 20000726; DE10050040 20001010; DE10052319 20001021; DE10118706 20010412
- 主分类号： G01N33/53
- IPC分类号： G01N33/53
摘要：
Mutants of the DNA sequence coding for the protease (FSAP) which activates blood clotting factor VII and single-chain plasminogen activators, the mutants comprising a G/C base exchange at nucleotide position 1177 and/or a G/A base exchange at nucleotide position 1601, are described. The corresponding protease has a Glu/Gln exchange at amino acid position 393 and/or a Gly/Glu exchange at amino acid position 534. Diagnostic methods which are used for detecting FSAP in body fluids or tissue cells and also for identifying patients with genetic heterozygous or homozygous FSAP expression are also described. In addition, antibodies against FSAP and its mutants are disclosed and diagnostic methods which can be used to detect antibodies against FSAP and its mutants are specified.
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