Invention Grant
- Patent Title: Amlodipine gentisate and a method of its preparation
- Patent Title (中): 氨氯地平龙胆和其制备方法
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Application No.: US10583438Application Date: 2004-12-15
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Publication No.: US07442714B2Publication Date: 2008-10-28
- Inventor: Jae-Sun Kim , Jin Young Choi , Je Ho Ryu , Nam Kyu Lee , Jeong-soo Jang , Woo Jae Jang , Key An Um , Do Seung Kum
- Applicant: Jae-Sun Kim , Jin Young Choi , Je Ho Ryu , Nam Kyu Lee , Jeong-soo Jang , Woo Jae Jang , Key An Um , Do Seung Kum
- Applicant Address: KR Kyungki-Do
- Assignee: SK Chemicals Co., Ltd.
- Current Assignee: SK Chemicals Co., Ltd.
- Current Assignee Address: KR Kyungki-Do
- Agency: Frommer Lawrence & Haug LLP
- Agent Ronald R. Santucci
- Priority: KR10-2003-0092001 20031216
- International Application: PCT/KR2004/003309 WO 20041215
- International Announcement: WO2005/058825 WO 20050630
- Main IPC: A61K31/44
- IPC: A61K31/44 ; C07D213/80
Abstract:
The present invention relates to an acid salt of amlodipine gentisate and a method of its preparation. More particularly, the present invention relates to a crystalline acid salt of amlodipine gentisate of the following formula 1 prepared by reacting amlodipine and gentisic acid, which is useful for the treatment of cardiovascular diseases and has the advantages of low toxicity, excellent stability, improved pharmaceutical efficacies and long-lasting concentration in blood.
Public/Granted literature
- US20070135495A1 Amlodipine gentisate and a method of its preparation Public/Granted day:2007-06-14
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