发明授权
- 专利标题: Antidiabetic bicyclic compounds
- 专利标题(中): 抗糖尿病双环化合物
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申请号: US11801841申请日: 2007-05-11
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公开(公告)号: US07442808B2公开(公告)日: 2008-10-28
- 发明人: Min Ge , Jiafang He , Fiona Wai Yu Lau , Gui-Bai Liang , Songnian Lin , Weiguo Liu , Shawn P. Walsh , Lihu Yang
- 申请人: Min Ge , Jiafang He , Fiona Wai Yu Lau , Gui-Bai Liang , Songnian Lin , Weiguo Liu , Shawn P. Walsh , Lihu Yang
- 申请人地址: US NJ Rahway
- 专利权人: Merck & Co., Inc.
- 当前专利权人: Merck & Co., Inc.
- 当前专利权人地址: US NJ Rahway
- 代理商 Phillippe L. Durette; Catherine D. Fitch
- 主分类号: C07D495/00
- IPC分类号: C07D495/00 ; C07D307/92 ; C07D209/94 ; C07D209/00 ; C07C229/00 ; C07C62/00 ; A61K31/38 ; A61K31/34 ; A61K31/19 ; A61K31/195 ; A61K31/40
摘要:
Tricyclic compounds containing a cyclopropyl carboxylic acid or carboxylic acid derivative (e.g. amide) fused to a bicyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
公开/授权文献
- US20070265332A1 Antidiabetic bicyclic compounds 公开/授权日:2007-11-15