发明授权
- 专利标题: Mutant isopropylmalate isomerase
- 专利标题(中): 突变异丙酸异丙酯
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申请号: US10508313申请日: 2003-03-19
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公开(公告)号: US07445915B2公开(公告)日: 2008-11-04
- 发明人: Masato Ikeda , Mikiro Hayashi , Junko Ohnishi , Satoshi Mitsuhashi , Hiroshi Mizoguchi , Satoshi Nakagawa
- 申请人: Masato Ikeda , Mikiro Hayashi , Junko Ohnishi , Satoshi Mitsuhashi , Hiroshi Mizoguchi , Satoshi Nakagawa
- 申请人地址: JP Tokyo
- 专利权人: Kyowa Hakko Kogyo Co., Ltd.
- 当前专利权人: Kyowa Hakko Kogyo Co., Ltd.
- 当前专利权人地址: JP Tokyo
- 代理机构: Nixon & Vanderhye P.C.
- 优先权: JP2002-076228 20020319
- 国际申请: PCT/JP03/03353 WO 20030319
- 国际公布: WO03/078620 WO 20030925
- 主分类号: C12N13/04
- IPC分类号: C12N13/04 ; C12P13/08 ; C12P13/10 ; C12P13/14 ; C12P13/22 ; C12P13/24 ; C07H21/04
摘要:
The present invention provides a polypeptide comprising an amino acid sequence in which at least one amino acid is deleted, substituted or added in an amino acid sequence of isopropylmalate isomerase derived from a microorganism belonging to coryneform bacteria, wherein a coryneform bacterium which produces the polypeptide comprising the amino acid sequence as the sole isopropylmalate isomerase exhibits a partial leucine requirement in a minimal medium; a DNA encoding the polypeptide, a recombinant DNA comprising the DNA, a microorganism transformed with the recombinant DNA, and a process for producing an L-amino acid using the microorganism.
公开/授权文献
- US20050130276A1 Mutated isopropylmalate isomerase 公开/授权日:2005-06-16