发明授权
- 专利标题： Peptidomimetic ligands for cellular receptors and ion channels
- 专利标题（中）： 肽模拟配体的细胞受体和离子通道
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申请号： US11512056申请日： 2006-08-29
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公开(公告)号： US07446115B2公开(公告)日： 2008-11-04
- 发明人: Paul E. Persons , Joanne M. Holland , James R. Hauske
- 申请人： Paul E. Persons , Joanne M. Holland , James R. Hauske
- 申请人地址： US MA Marlborough
- 专利权人： Sepracor, Inc.
- 当前专利权人： Sepracor, Inc.
- 当前专利权人地址： US MA Marlborough
- 代理机构： Edwards Angell Palmer & Dodge LLP
- 代理商 Peter F. Corless
- 主分类号： A61K31/40
- IPC分类号： A61K31/40 ; A61K31/4025 ; A61K31/472 ; C07D207/14 ; C07D211/56 ; C07D217/12 ; C07D223/16
摘要：
One aspect of the present invention relates to novel peptidomometic compounds. A second aspect of the present invention relates to the use of the novel peptidomimetic compounds as ligands—agonists or antagonists—for various cellular receptors, e.g., G-protein-coupled receptors and opioid receptors, and various cellular ion channels, e.g., sodium and calcium. In certain embodiments, compounds of the present invention preferentially or selectively inhibit sodium or calcium ion channels. In certain embodiments, compounds of the present invention preferentially or selectively agonize or antagonize μ opioid receptors. In certain embodiments, compounds of the present invention preferentially or selectively inhibit sodium or calcium ion channels and agonize or antagonize μ-opioid receptors.
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