Disclosed is a clamp for securing cables or other elongate members used in surgical fastening procedures. The clamp advantageously applies a clamping force to the cable without direct contact with the cable, thereby reducing abrasion and shear forces applied to the cable. The disclosed clamps have a saddle member, platen or both that are movably mounted with respect to the housing and a lever, in cooperation with a cam surface, that allows the saddle member, platen or both to selectively clamp the cable. The lever may have several locking positions to provide optimum clamping force to different sized cables.