发明授权
- 专利标题: Method for improvement of tolerance for therapeutically effective agents delivered by inhalation
- 专利标题(中): 通过吸入改善治疗有效药物耐受性的方法
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申请号: US11045234申请日: 2005-01-28
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公开(公告)号: US07452524B2公开(公告)日: 2008-11-18
- 发明人: Thomas Hofmann , Alan Bruce Montgomery , Kevin Stapleton , William R. Baker
- 申请人: Thomas Hofmann , Alan Bruce Montgomery , Kevin Stapleton , William R. Baker
- 申请人地址: US CA Foster City
- 专利权人: Gilead Sciences, Inc.
- 当前专利权人: Gilead Sciences, Inc.
- 当前专利权人地址: US CA Foster City
- 代理机构: Peters Verny, LLP
- 代理商 Hana Verny
- 主分类号: A61K9/00
- IPC分类号: A61K9/00 ; A61K9/12
摘要:
A method for improvement of tolerance for therapeutically effective agents delivered by inhalation comprising a pretreatment of a patient with a nebulized lidocaine or a lidocaine-like compound administered immediately or up to about thirty minutes before administration of the primary therapeutically effective agent. The pretreatment of the patient with the nebulized lidocaine or a lidocaine-like compound improves airway tolerance and deposition of the agent in the lungs and makes such deposition more safe, efficacious, controllable and predictable. The method of the invention is especially useful for enhancement of deposition of immunosuppressive agents in the lung(s) of transplant patients, improved tolerance of the drugs by reducing cough, and improving pulmonary drug deposition.