发明授权
- 专利标题： Death domain containing receptor 4 antibodies and methods
- 专利标题（中）： 含有受体4抗体的死亡域和方法
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申请号： US10648786申请日： 2003-08-27
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公开(公告)号： US07452538B2公开(公告)日： 2008-11-18
- 发明人: Jian Ni , Craig A. Rosen , James G. Pan , Reiner L. Gentz , Vishva M. Dixit
- 申请人： Jian Ni , Craig A. Rosen , James G. Pan , Reiner L. Gentz , Vishva M. Dixit
- 申请人地址： US MD Rockville US MI Ann Arbor
- 专利权人： Human Genome Sciences, Inc.,The Regents of the University of Michigan
- 当前专利权人： Human Genome Sciences, Inc.,The Regents of the University of Michigan
- 当前专利权人地址： US MD Rockville US MI Ann Arbor
- 代理机构： Sterne, Kessler, Goldstein & Fox P.L.L.C.
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61K38/18 ; A61K38/19 ; C07K16/30
摘要：
The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity and methods for using DR4 polynucleotides and polypeptides. The invention also relates to the treatment of diseases associated with reduced or increased levels of apoptosis using antibodies specific for DR4, which may be agonists and/or antagonists of DR4 activity.
公开/授权文献
- US20050112090A9 Death domain containing receptor 4 公开/授权日：2005-05-26
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