发明授权
- 专利标题： Macrocycles useful in the treatment of alzheimer's disease
- 专利标题（中）： 可用于治疗阿尔茨海默病的大环
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申请号： US11208382申请日： 2005-08-19
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公开(公告)号： US07456163B2公开(公告)日： 2008-11-25
- 发明人: Shon R. Pulley , James P. Beck , Ruth E. TenBrink , Jon S. Jacobs
- 申请人： Shon R. Pulley , James P. Beck , Ruth E. TenBrink , Jon S. Jacobs
- 申请人地址： US CA So. San Francisco
- 专利权人： Elan Pharmaceuticals, Inc.
- 当前专利权人： Elan Pharmaceuticals, Inc.
- 当前专利权人地址： US CA So. San Francisco
- 代理机构： McDonnell Boehnen Hulbert & Berghoff LLP
- 主分类号： C07D273/02
- IPC分类号： C07D273/02 ; C07D291/08 ; C07D413/04 ; C07D413/12 ; C07D498/08 ; A61P25/28
摘要：
The present invention is macrocycles of the formula (X): for treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme for the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.