发明授权
US07456192B2 3β-amino azabicyclooctane heteroaromatic amid derivatives preparation method and therapeutic uses thereof
有权
3β-氨基偶氮二异辛烷杂芳族衍生物的制备方法及其治疗用途
- 专利标题: 3β-amino azabicyclooctane heteroaromatic amid derivatives preparation method and therapeutic uses thereof
- 专利标题(中): 3β-氨基偶氮二异辛烷杂芳族衍生物的制备方法及其治疗用途
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申请号: US10494639申请日: 2002-10-30
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公开(公告)号: US07456192B2公开(公告)日: 2008-11-25
- 发明人: Thierry Imbert , Barbara Monse , Wouter Koek
- 申请人: Thierry Imbert , Barbara Monse , Wouter Koek
- 申请人地址: FR Boulogne Billancourt
- 专利权人: Pierre Fabre Medicament
- 当前专利权人: Pierre Fabre Medicament
- 当前专利权人地址: FR Boulogne Billancourt
- 代理机构: Birch, Stewart, Kolasch & Birch, LLP
- 优先权: FR0114220 20011102
- 国际申请: PCT/FR02/03737 WO 20021030
- 国际公布: WO03/037904 WO 20030508
- 主分类号: A61K31/4353
- IPC分类号: A61K31/4353 ; A61K31/4365 ; A61K31/46 ; C07D471/04 ; C07D419/04
摘要:
The invention concerns compounds of general formula 1, wherein: A, B, D and E represent one or two nitrogen atoms, the others being carbon atoms; X represents a S or, a O, thereby forming a bicyclic fused heteroaromatic, such as thieno[2,3-b]pyridine, furo[2,3-b]pyridine, thieno[3,2-b]pyridine, furo[3,2-b]pyridine, thieno[2,3-b]pyrazine, furo[2,3-b]pyrazine, thieno[2,3-c]pyridine, furo[2,3-c]pyridine, thieno[3,2-c]pyridine and furo[3,2-c]pyridine; R1 represents a linear or branched C1-C6 alkoxy group, a linear or branched C1-C6 alkylthio group; R2 represents a linear, branched, cyclic C2-C8 group, a 2- or 3-thienylmethyl group, or a benzyl group optionally substituted by one or several halogens, F, Cl, Br, I, C1-C4alkyl, C1-C4 alkoxy, CF3, CN, NO2, OH; and their pharmaceutically acceptable salts. Said compounds are anti-dopaminergic agents.
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