发明授权
- 专利标题： Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders
- 专利标题（中）： 用于治疗代谢紊乱的化合物，药物组合物和方法
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申请号： US11436732申请日： 2006-05-17
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公开(公告)号： US07465804B2公开(公告)日： 2008-12-16
- 发明人: Jonathan Houze , Jiwen Liu , Zhihua Ma , Julio C. Medina , Michael J. Schmitt , Rajiv Sharma , Ying Sun , Yingcai Wang , Liusheng Zhu
- 申请人： Jonathan Houze , Jiwen Liu , Zhihua Ma , Julio C. Medina , Michael J. Schmitt , Rajiv Sharma , Ying Sun , Yingcai Wang , Liusheng Zhu
- 申请人地址： US CA Thousand Oaks
- 专利权人： Amgen Inc.
- 当前专利权人： Amgen Inc.
- 当前专利权人地址： US CA Thousand Oaks
- 代理商 Bernard P. Friedrichsen
- 主分类号： C07D263/32
- IPC分类号： C07D263/32 ; C07D257/04 ; C07D249/04 ; C07D249/08 ; C07D277/22 ; C07D277/24 ; C07C59/13
摘要：
The present invention provides compounds useful, for example, for modulating insulin levels in a subject, having the general formula I: wherein Q is an optionally substituted phenyl; L is a bond or O; P is a benzene or an optionally substituted thiazole ring; and R1 has the values provided herein. The present invention also provides compositions, uses, and methods for use of the compounds, for instance, for treatment of type II diabetes.