发明授权
- 专利标题： Yohimbine derivatives and use thereof
- 专利标题（中）： 育亨宾衍生物及其用途
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申请号： US11210206申请日： 2005-08-23
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公开(公告)号： US07470703B1公开(公告)日： 2008-12-30
- 发明人: Duane D. Miller , Bob M. Moore, II , Suni Mustafa , Dennis R. Feller , Supriya A. Bavadekar
- 申请人： Duane D. Miller , Bob M. Moore, II , Suni Mustafa , Dennis R. Feller , Supriya A. Bavadekar
- 申请人地址： US TN Knoxville US MS University
- 专利权人： The University of Tennessee Research Foundation,The University of Mississippi
- 当前专利权人： The University of Tennessee Research Foundation,The University of Mississippi
- 当前专利权人地址： US TN Knoxville US MS University
- 代理机构： Nixon Peabody LLP
- 主分类号： A61K31/4745
- IPC分类号： A61K31/4745 ; C07D471/16
摘要：
Yohimbine derivatives are disclosed having modification of the C-16 carboxyl group to include a sidechain and where the resulting derivative does not possess a second yohimbine pharmacophore (i.e., the compound is not a yohimbine dimer). The yohimbine derivatives of the present invention are preferably characterized by selective activity as α2c-AR antagonists. Use of the compounds, or pharmaceutical composition containing them, for treating or preventing an α2c adrenergic receptor mediated condition or disorder, and for antagonizing activity of an α2c adrenergic receptor are also disclosed.
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