发明授权
- 专利标题： Stable retrovirus and methods of use
- 专利标题（中）： 稳定的逆转录病毒及使用方法
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申请号： US11677110申请日： 2007-02-21
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公开(公告)号： US07485446B2公开(公告)日： 2009-02-03
- 发明人: Halong N. Vu , Daniel W. Pack , Joshua Ramsey
- 申请人： Halong N. Vu , Daniel W. Pack , Joshua Ramsey
- 申请人地址： US IL Urbanail
- 专利权人： The Board of Trustees of the University of Illinois
- 当前专利权人： The Board of Trustees of the University of Illinois
- 当前专利权人地址： US IL Urbanail
- 代理机构： Licata & Tyrrell P.C.
- 主分类号： C12N9/50
- IPC分类号： C12N9/50 ; C12Q1/70 ; C12N9/00 ; C12N9/48
摘要：
The present invention is a mutant retroviral protease which confers an increase in retroviral stability. Retroviruses expressing the instant mutant retroviral protease exhibit at least a 2-fold increase in infectivity half-life as compared to wild-type retrovirus. Unexpectedly, a Gly119Glu mutation in the protease enhances retroviral stability in the presence of various wild-type envelope proteins including wild-type amphotropic, ecotropic and 10A1 murine leukemia viruses. The improved stability of the mutant retrovirus leads to more facile virus production and enhanced infection efficiency.
公开/授权文献
- US20070196386A1 Stable retrovirus and methods of use 公开/授权日：2007-08-23