发明授权
- 专利标题: Medicinal composition
- 专利标题(中): 药用成分
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申请号: US10526780申请日: 2002-09-12
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公开(公告)号: US07485665B2公开(公告)日: 2009-02-03
- 发明人: Akihiko Kitajima , Osamu Kamoda , Akihiro Ohsako , Toshiharu Yanagi
- 申请人: Akihiko Kitajima , Osamu Kamoda , Akihiro Ohsako , Toshiharu Yanagi
- 申请人地址: JP Osaka
- 专利权人: Nagase Chemtex Corporation
- 当前专利权人: Nagase Chemtex Corporation
- 当前专利权人地址: JP Osaka
- 代理机构: Wenderoth, Lind & Ponack, L.L.P.
- 国际申请: PCT/JP02/09390 WO 20020912
- 国际公布: WO2004/024143 WO 20040325
- 主分类号: A61K31/40
- IPC分类号: A61K31/40 ; C07D207/04
摘要:
The present invention relates to an ameliorant for improving the movement of the digestive tract comprising, as an active ingredient, 4-amino-5-chloro-2-methoxy-N-[(2S,4S)-2-hydroxymethyl-4-pyrrolidinyl]benzamide or an acid addition salt thereof which is a metabolite of 4-amino-5-chloro-2-methoxy-N-[(2S,4S)-1-ethyl-2-hydroxymethyl-4-pyrrolidinyl]benzamide or an acid addition salt thereof, having high biding affinity for a serotonin receptor 4 (5HT4) and causing no arteritis and thrombus formation; a medicinal composition for improving the movement of the digestive tract comprising the said ameliorant and a pharmaceutically acceptable carrier; and a treating method for promoting the movement of the digestive tract, which comprises using the said medicinal composition for improving the movement of the digestive tract.
公开/授权文献
- US20050239861A1 Medicinal composition 公开/授权日:2005-10-27
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