发明授权
- 专利标题： Variolin derivatives and their use as antitumor agents
- 专利标题（中）： 异喹啉衍生物及其作为抗肿瘤剂的用途
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申请号： US10483525申请日： 2002-07-11
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公开(公告)号： US07495000B2公开(公告)日： 2009-02-24
- 发明人: Modesto Remuiñan , Juan Jose Gonzalez , Carlos Del Pozo , Carmen Cuevas , Simon Munt , Regan James Anderson , Andres Francesh , Jonathan Charles Morris , Ignacio Manzanares
- 申请人： Modesto Remuiñan , Juan Jose Gonzalez , Carlos Del Pozo , Carmen Cuevas , Simon Munt , Regan James Anderson , Andres Francesh , Jonathan Charles Morris , Ignacio Manzanares
- 申请人地址： ES Madrid
- 专利权人： Pharma Mar, S.A.
- 当前专利权人： Pharma Mar, S.A.
- 当前专利权人地址： ES Madrid
- 代理机构： Fish & Richardson P.C.
- 优先权： GB0116966.3 20010711
- 国际申请： PCT/GB02/03197 WO 20020711
- 国际公布： WO03/006457 WO 20030123
- 主分类号： A61K31/506
- IPC分类号： A61K31/506 ; C07D239/06
摘要：
Variolin derivatives of formula (5) are provided, wherein the substituent groups defined by X2, R1, R2, R3, R6, R7 and R12 are each independently selected from the group consisting of H, OH, OR′, SH, SR′, SOR′, SO2R′, NO2, NH2, NHR′, N(R′)2, NHCOR′, NHSO2R′, CN, halogen, ═O, C(═O)H, C(═O)R′, CO2H, CO2R′, carboxyalkyl, C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl and substituted or unsubstituted heteroaromatic; wherein each of the R′ groups is independently selected from the group consisting of H, OH, SH, NO2, NH2, CN, halogen, ═O, C(═O)H, C(═O)CH3, CO2H, CO2CH3, C1-C12 alkyl, C2-C12 alkenyl, C2-C12alkynyl, aryl, aralkyl and heteroaromatic; wherein the pairs of groups R1 and R2, R2 and R3, R3 and R12, R12 and R6, or R6 and R7 may be joined into a carbocyclic or heterocyclic ring system.
公开/授权文献
- US20060235223A1 Variolin derivatives and their use as antitumor agents 公开/授权日：2006-10-19
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