发明授权
US07495003B2 8-(3-amino-piperidin-1-yl)-7-(but-2-ynyl)-xanthines, the preparation thereof and their use as pharmaceutical compositions
有权
8-（3-氨基 - 哌啶-1-基）-7-（丁-2-炔基） - 黄嘌呤，其制备及其作为药物组合物的用途
- 专利标题： 8-(3-amino-piperidin-1-yl)-7-(but-2-ynyl)-xanthines, the preparation thereof and their use as pharmaceutical compositions
- 专利标题（中）： 8-（3-氨基 - 哌啶-1-基）-7-（丁-2-炔基） - 黄嘌呤，其制备及其作为药物组合物的用途
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申请号： US11218057申请日： 2005-09-01
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公开(公告)号： US07495003B2公开(公告)日： 2009-02-24
- 发明人: Matthias Eckhardt , Frank Himmelsbach , Elke Langkopf , Mohammad Tadayyon , Leo Thomas
- 申请人： Matthias Eckhardt , Frank Himmelsbach , Elke Langkopf , Mohammad Tadayyon , Leo Thomas
- 申请人地址： DE Ingelheim
- 专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人地址： DE Ingelheim
- 代理商 Michael P. Morris; Mary-Ellen M. Devlin; David L. Kershner
- 优先权： DE102004043944 20040911
- 主分类号： C07D473/06
- IPC分类号： C07D473/06 ; C07D519/00 ; C07D473/04 ; A61K31/522 ; A61P3/10
摘要：
The application relates to new substituted xanthines of general formula wherein R1 and R2 are defined as in claims 1 to 11, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).