发明授权
US07497855B2 Method and device for the controlled delivery of parathyroid hormone
有权
用于甲状旁腺激素受控递送的方法和装置
- 专利标题: Method and device for the controlled delivery of parathyroid hormone
- 专利标题(中): 用于甲状旁腺激素受控递送的方法和装置
-
申请号: US10654761申请日: 2003-09-04
-
公开(公告)号: US07497855B2公开(公告)日: 2009-03-03
- 发明人: Dennis Ausiello , John T. Santini, Jr. , Stephen J. Herman , James H. Prescott , Scott A. Uhland , John M. Maloney , Benjamin F. Polito
- 申请人: Dennis Ausiello , John T. Santini, Jr. , Stephen J. Herman , James H. Prescott , Scott A. Uhland , John M. Maloney , Benjamin F. Polito
- 申请人地址: US MA Bedford
- 专利权人: MicroCHIPS, Inc.
- 当前专利权人: MicroCHIPS, Inc.
- 当前专利权人地址: US MA Bedford
- 代理机构: Sutherland Asbill & Brennan LLP
- 主分类号: A61K9/22
- IPC分类号: A61K9/22
摘要:
Method and devices are provided for extended and controlled delivery of parathyroid hormone to a patient. The method includes implanting a medical device into the patient, the medical device comprising a substrate, a plurality of reservoirs in the substrate, a release system contained in each of the reservoirs, wherein the release system comprises parathyroid hormone; and controllably releasing a pharmaceutically effective amount of the parathyroid hormone from the reservoirs. The parathyroid hormone can be released intermittently, such as once daily over an extended period (e.g., two months, ten months, or more.). The device can further include reservoirs containing a bone resorption inhibitor or other drug for release. The devices are useful in delivering PTH for the treatment and prevention of bone loss, such as associated with osteoporosis.