发明授权
US07498330B2 4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrazine-6-carboxamide compounds
失效
4-氧代-4,6,7,8-四氢 - 吡咯并[1,2-a]吡嗪-6-甲酰胺化合物
- 专利标题: 4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrazine-6-carboxamide compounds
- 专利标题(中): 4-氧代-4,6,7,8-四氢 - 吡咯并[1,2-a]吡嗪-6-甲酰胺化合物
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申请号: US11079638申请日: 2005-03-14
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公开(公告)号: US07498330B2公开(公告)日: 2009-03-03
- 发明人: Guillaume De Nanteuil , Philippe Gloanec , Jean-Gilles Parmentier , Alain Benoist , Alain Rupin , Marie-Odile Vallez , Tony Verbeuren
- 申请人: Guillaume De Nanteuil , Philippe Gloanec , Jean-Gilles Parmentier , Alain Benoist , Alain Rupin , Marie-Odile Vallez , Tony Verbeuren
- 申请人地址: FR Courbevoie Cedex
- 专利权人: Les Laboratories Servier
- 当前专利权人: Les Laboratories Servier
- 当前专利权人地址: FR Courbevoie Cedex
- 代理机构: Hueschen and Sage
- 优先权: FR0402841 20040319
- 主分类号: A01N43/66
- IPC分类号: A01N43/66 ; A61K31/53 ; C07D241/36
摘要:
Compound of formula (I): wherein: represents 1-oxidopyridyl substituted by the remainder of the molecule in any one of the positions 2, 3 and 4, m and n, which may be identical or different, each represent an integer of from 1 to 3, R1 represents hydrogen or alkyl, R2 and R3, which may be identical or different, each represent an atom or group selected from hydrogen, halogen, alkyl, hydroxy, acyloxy and alkoxy, or, together with the carbon atom carrying them, form a cycloalkane having from 3 to 6 carbon atoms, R4 and R5 each represent hydrogen, or are adjacent and, together with the carbon atoms carrying them, form a benzo ring, Ar represents aryl or heteroaryl. Medicinal products containing the same which are useful as thrombin inhibitors.