发明授权
US07498335B2 Method of producing an antiangiogenic or vascular permeability reducing effect
失效
产生抗血管生成或血管通透性降低作用的方法
- 专利标题： Method of producing an antiangiogenic or vascular permeability reducing effect
- 专利标题（中）： 产生抗血管生成或血管通透性降低作用的方法
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申请号： US10220140申请日： 2001-03-01
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公开(公告)号： US07498335B2公开(公告)日： 2009-03-03
- 发明人: Laurent Francois Andre Hennequin , Graham Charles Crawley , Darren McKerrecher , Patrick Ple , Jeffrey Philip Poyser , Christine Marie Paul Lambert
- 申请人： Laurent Francois Andre Hennequin , Graham Charles Crawley , Darren McKerrecher , Patrick Ple , Jeffrey Philip Poyser , Christine Marie Paul Lambert
- 申请人地址： CH Sodertalje
- 专利权人： AstraZeneca AB
- 当前专利权人： AstraZeneca AB
- 当前专利权人地址： CH Sodertalje
- 代理机构： Morgan, Lewis & Bockius LLP
- 优先权： EP00400595 20000306
- 国际申请： PCT/GB01/00863 WO 20010301
- 国际公布： WO01/66099 WO 20010913
- 主分类号： A61K31/517
- IPC分类号： A61K31/517
摘要：
The invention concerns the use of a quinazoline derivative of Formula (I) wherein Q1 includes a quinazoline ring optionally substituted with a group such as halogeno, trifluoromethyl and cyano, or a group of the formula: Q3—X1— wherein X1 includes a direct bond and O and Q3includes aryl, aryl-(1-6C)alkyl, heterocyclyl and heterocyclyl-(1-6C)alkyl; each of R2 and R3 is hydrogen or (1-6C)alkyl; Z includes O, S and NH; and Q2 includes aryl and aryl-(1-3C)alkyl or a pharmaceutically-acceptable salt thereof, in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in a warm-blooded animal such as a human.
公开/授权文献
- US20030225111A1 Therapy 公开/授权日：2003-12-04