Invention Grant
- Patent Title: Human ADAM-10 inhibitors
- Patent Title (中): 人ADAM-10抑制剂
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Application No.: US10498338Application Date: 2002-12-13
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Publication No.: US07498358B2Publication Date: 2009-03-03
- Inventor: S. David Brown , Lynne Canne-Bannen , Erick Wang Co , Vasu Jammalamadaka , Rickard George Khoury , Moon Hwan Kim , Donna T. Le , Amy Lew Tsuhako , Morrison B. Mac , Shumeye Mamo , John M. Nuss , Michael P. Prisbylla , Wei Xu
- Applicant: S. David Brown , Lynne Canne-Bannen , Erick Wang Co , Vasu Jammalamadaka , Rickard George Khoury , Moon Hwan Kim , Donna T. Le , Amy Lew Tsuhako , Morrison B. Mac , Shumeye Mamo , John M. Nuss , Michael P. Prisbylla , Wei Xu
- Applicant Address: US CA South San Francisco
- Assignee: Exelixis, Inc.
- Current Assignee: Exelixis, Inc.
- Current Assignee Address: US CA South San Francisco
- International Application: PCT/US02/39816 WO 20021213
- International Announcement: WO03/051825 WO 20030626
- Main IPC: C07C311/19
- IPC: C07C311/19 ; C07C311/29 ; C07C259/06 ; C07C259/08 ; C07D213/32 ; C07D213/68 ; A61K31/16 ; A61K31/44 ; A61P19/02 ; A61P35/00 ; A61P9/10
Abstract:
The present invention provides compounds useful for inhibiting the ADAM-10 protein. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role. The invention also provides methods for making bis-aryl ether sulfonyl chlorides and ADAM-10 modulators therefrom.
Public/Granted literature
- US20050227973A1 Human adam-10 inhibitors Public/Granted day:2005-10-13
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