Disclosed is a method for removing signal interference in a local radio communication device mounted in a mobile terminal. The method comprises receiving information on a channel in use from the mobile terminal in session; determining based on the received channel information whether a harmonic component of a channel frequency used by the mobile terminal belongs to a frequency band used by the local radio communication device; and assigning a channel in a frequency band with none of the harmonic component among the frequency band used by the local radio communication device as a channel of the local radio communication device, when the harmonic component of the channel frequency used by the mobile terminal belongs to the frequency band used by the local radio communication device.