发明授权
US07507729B2 Substituted imidazo-[1,5-a][1,2,4]triazolo[1,5-d][1,4] benzodiazepine derivatives
失效
取代的咪唑并[1,5-a] [1,2,4]三唑并[1,5-d] [1,4]苯并二氮杂衍生物
![Substituted imidazo-[1,5-a][1,2,4]triazolo[1,5-d][1,4] benzodiazepine derivatives](/docs/US/2009-03-24/US07507729B2/abs.jpg.600x600.jpg)
- 专利标题： Substituted imidazo-[1,5-a][1,2,4]triazolo[1,5-d][1,4] benzodiazepine derivatives
- 专利标题（中）： 取代的咪唑并[1,5-a] [1,2,4]三唑并[1,5-d] [1,4]苯并二氮杂衍生物
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申请号： US11542944申请日： 2006-10-04
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公开(公告)号： US07507729B2公开(公告)日： 2009-03-24
- 发明人: Bernd Buettelmann , Henner Knust , Andrew Thomas
- 申请人： Bernd Buettelmann , Henner Knust , Andrew Thomas
- 申请人地址： US NJ Nutley
- 专利权人： Hoffmann-La Roche Inc.
- 当前专利权人： Hoffmann-La Roche Inc.
- 当前专利权人地址： US NJ Nutley
- 代理商 George W. Johnston; Patricia S. Rocha-Tramaloni; Kimberly J. Prior
- 优先权： EP05109446 20051011
- 主分类号： A61P25/28
- IPC分类号： A61P25/28 ; A61K31/55 ; C07D243/00
![Substituted imidazo-[1,5-a][1,2,4]triazolo[1,5-d][1,4] benzodiazepine derivatives](/abs-image/US/2009/03/24/US07507729B2/abs.jpg.150x150.jpg)
摘要：
The present invention is concerned with substituted imidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]benzodiazepine derivatives of the following formula wherein the definition of substituents is described in the claims. This class of compounds shows high affinity and selectivity for GABA A α5 receptor binding sites and might be useful as a cognitive enhancer or for the treatment of cognitive disorders like Alzheimer's disease.