发明授权
US07511146B2 2-substituted benzimidazole piperidines analogs as selective melanin concentrating hormone receptor antagonists for the treatment of obesity and related disorders
失效
2-取代的苯并咪唑哌啶类似物作为选择性黑色素浓缩激素受体拮抗剂用于治疗肥胖症和相关疾病
- 专利标题： 2-substituted benzimidazole piperidines analogs as selective melanin concentrating hormone receptor antagonists for the treatment of obesity and related disorders
- 专利标题（中）： 2-取代的苯并咪唑哌啶类似物作为选择性黑色素浓缩激素受体拮抗剂用于治疗肥胖症和相关疾病
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申请号： US10926557申请日： 2004-08-26
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公开(公告)号： US07511146B2公开(公告)日： 2009-03-31
- 发明人: Duane A. Burnett , Wen-Lian Wu , Thavalakulamgara K. Sasikumar , William J. Greenlee , Mary Ann Caplen , Tao Guo , Rachael Catherine Hunter
- 申请人： Duane A. Burnett , Wen-Lian Wu , Thavalakulamgara K. Sasikumar , William J. Greenlee , Mary Ann Caplen , Tao Guo , Rachael Catherine Hunter
- 申请人地址： US NJ Kenilworth
- 专利权人： Schering Corporation
- 当前专利权人： Schering Corporation
- 当前专利权人地址： US NJ Kenilworth
- 代理商 Palaiyur S. Kalyanaraman; William Y. Lee
- 主分类号： C07D211/32
- IPC分类号： C07D211/32
摘要：
The present invention discloses compounds of formula I wherein Ar, Y, m, n, R1 and R4 are herein defined, said compounds being novel antagonists for melanin-concentrating hormone (MCH), as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such MCH antagonists as well as methods of using them to treat obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes.
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