发明授权
- 专利标题： Peptide carrier for delivering siRNA into mammalian cells
- 专利标题（中）： 用于将siRNA递送到哺乳动物细胞中的载体
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申请号： US10831342申请日： 2004-04-26
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公开(公告)号： US07514530B2公开(公告)日： 2009-04-07
- 发明人: Gilles Divita , May Catherine Morris , Frédéric Heitz , Federica Simeoni
- 申请人： Gilles Divita , May Catherine Morris , Frédéric Heitz , Federica Simeoni
- 申请人地址： FR Paris
- 专利权人： Centre National de la Recherche Scientifique
- 当前专利权人： Centre National de la Recherche Scientifique
- 当前专利权人地址： FR Paris
- 代理机构： Morgan, Lewis & Bockius LLP
- 主分类号： C07K7/00
- IPC分类号： C07K7/00 ; C07H21/04 ; A61K31/70
摘要：
Complex comprising a peptide carrier of SEQ ID NO:1 GALFLGFLGAAGSTMGAWSQPKR1KRKVR2 and an appropriate siRNA, wherein R1 represents any amino acid residue and more preferably K or S, R2 is null or represents one of the following groups: cysteamide, cysteine, thiol, amide, linear or ramified C1-C6 alkyl optionally substituted, primary or secondary amine, osidic derivative, lipid, phospholipid or cholesterol and said siRNA is selected to silence a target mRNA.