Invention Grant
- Patent Title: Bichalcophenes and their prodrugs as antiprotozoal agents
- Patent Title (中): 双氯巴酚及其前药作为抗原虫药
-
Application No.: US11435323Application Date: 2006-05-16
-
Publication No.: US07517893B2Publication Date: 2009-04-14
- Inventor: Richard R. Tidwell , David W. Boykin , Chad Stephens , Mohamed A. Ismail , W. David Wilson , Reto Brun , Karl Werbovetz
- Applicant: Richard R. Tidwell , David W. Boykin , Chad Stephens , Mohamed A. Ismail , W. David Wilson , Reto Brun , Karl Werbovetz
- Applicant Address: US NC Chapel Hill US GA Atlanta
- Assignee: The University of North Carolina at Chapel Hill,Georgia State University Research Foundation, Inc.
- Current Assignee: The University of North Carolina at Chapel Hill,Georgia State University Research Foundation, Inc.
- Current Assignee Address: US NC Chapel Hill US GA Atlanta
- Agency: Jenkins, Wilson, Taylor & Hunt, P.A.
- Main IPC: C07D401/02
- IPC: C07D401/02 ; A61K31/44
Abstract:
Novel dicationic bichalcophene compounds are described. The presently disclosed novel dicationic bichalcophene compounds exhibit in vitro activity versus Trypanosoma brucei rhodesiense, Plasmodium falciparum, or Leishmania donovani comparable to that of pentamidine and furamidine. Some of the novel dicationic bichalcophene compounds displayed good activity in vivo in a murine model of a Trypanosoma brucei rhodesiense infection.
Public/Granted literature
- US20060293540A1 Novel bichalcophenes and their prodrugs as antiprotozoal agents Public/Granted day:2006-12-28
Information query
