Systems, methods and apparatus are provided through which a specialized back-projection process reconstructs a finely detailed and crisp three-dimensional image (3-D) from a series of two-dimensional (2-D) images by pre-filtering the 2-D images with a first group of settings before back-projecting the 2-D images into a 3-D image, and then post-filtering the 3-D image with another group of settings. In some embodiments, the first group of settings and the second group of settings are synergistically optimized in relation to each other to provide emphasis on a structure of interest in the object.