发明授权
- 专利标题： Methods and compositions for P2X receptor calcium entry channels and other calcium entry mechanisms
- 专利标题（中）： P2X受体钙通道和其他钙进入机制的方法和组成
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申请号： US10542555申请日： 2004-01-20
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公开(公告)号： US07524517B2公开(公告)日： 2009-04-28
- 发明人: Erik Schwiebert , Akos Zsembery
- 申请人： Erik Schwiebert , Akos Zsembery
- 申请人地址： US AL Birmingham
- 专利权人： UAB Research Foundation
- 当前专利权人： UAB Research Foundation
- 当前专利权人地址： US AL Birmingham
- 代理机构： Ballard Spahr Andrews & Ingersoll LLP
- 国际申请： PCT/US2004/001298 WO 20040120
- 国际公布： WO2004/064742 WO 20040805
- 主分类号： A61K33/30
- IPC分类号： A61K33/30 ; A61K31/315 ; A61K31/7076 ; A61P11/00 ; A61P11/06
摘要：
This invention relates generally to a method of increasing cytosolic Ca2+ levels in mammalian cells comprising contacting P2X receptor Ca2+ entry channels or any and all other Ca2+ entry channels or mechanisms on the cell with an effective amount of a small molecule, and a composition comprising the small molecule in a delivery system. The invention has broad applicability in the pharmaceutical industry as a method of treating airway diseases (such as cystic fibrosis and asthma), ailments of the lung and airways (such as those caused by common cold pathogens or allergens in allergy), kidney diseases and renal hypertensive disorders (such as polycystic kidney disease and salt-sensitive hypertension syndromes), and endocrine disorders (such as diabetes).
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