发明授权
US07524841B2 4,4-disubstituted piperidine derivatives having CCR3 antagonism
失效
具有CCR3拮抗作用的4,4-二取代哌啶衍生物
- 专利标题： 4,4-disubstituted piperidine derivatives having CCR3 antagonism
- 专利标题（中）： 具有CCR3拮抗作用的4,4-二取代哌啶衍生物
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申请号： US10512339申请日： 2003-04-16
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公开(公告)号： US07524841B2公开(公告)日： 2009-04-28
- 发明人: Yoshiyuki Matsumoto , Minoru Imai , Yoshiyuki Sawai , Susumu Takeuchi , Akinobu Nakanishi , Kunio Minamizono , Tomonori Yokoyama
- 申请人： Yoshiyuki Matsumoto , Minoru Imai , Yoshiyuki Sawai , Susumu Takeuchi , Akinobu Nakanishi , Kunio Minamizono , Tomonori Yokoyama
- 申请人地址： JP Osaka
- 专利权人： Teijin Limited
- 当前专利权人： Teijin Limited
- 当前专利权人地址： JP Osaka
- 代理机构： Sughrue Mion, PLLC
- 优先权： JP2002-123883 20020425; JP2002-240508 20020821
- 国际申请： PCT/JP03/04842 WO 20030416
- 国际公布： WO03/091245 WO 20031106
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; C07D403/12 ; C07D403/14 ; A61K31/4523 ; A61K31/454 ; A61P11/06
摘要：
The invention provides low molecular compounds having activity which inhibits binding of CCR3 ligands to CCR3 on target cells, i.e. CCR3 antagonists. The invention also provides 4,4-(disubstituted)piperidine derivatives represented by formula (I) below, pharmaceutically acceptable acid adducts thereof, or pharmaceutically acceptable C1-C6 alkyl adducts thereof, as well as pharmaceutical compositions comprising them as effective ingredients, which are useful for treatment or prevention of diseases associated with CCR3, such as asthma and allergic rhinitis.