发明授权
US07531662B2 Cinchona-alkaloid-based catalysts, and asymmetric alcoholysis of cyclic anhydrides using them
有权
Cinchona-生物碱类催化剂和使用它们的环状酸酐的不对称醇解
- 专利标题： Cinchona-alkaloid-based catalysts, and asymmetric alcoholysis of cyclic anhydrides using them
- 专利标题（中）： Cinchona-生物碱类催化剂和使用它们的环状酸酐的不对称醇解
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申请号： US10865490申请日： 2004-06-10
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公开(公告)号： US07531662B2公开(公告)日： 2009-05-12
- 发明人: Li Deng , Xiaofeng Liu
- 申请人： Li Deng , Xiaofeng Liu
- 申请人地址： US MA Waltham
- 专利权人： Brandeis University
- 当前专利权人： Brandeis University
- 当前专利权人地址： US MA Waltham
- 代理机构： Foley Hoag LLP
- 代理商 Dana M. Gordon
- 主分类号： C07D453/04
- IPC分类号： C07D453/04 ; A61K31/47
摘要：
One aspect of the present invention relates to cinchona-alkaloid-based catalysts. A second aspect of the invention relates to a method of preparing a derivatized cinchona alkaloid catalyst by reacting a cinchona-alkaloid with base and a compound that has a suitable leaving group. Another aspect of the present invention relates to a method of preparing a chiral, non-racemic compound from a prochiral cyclic anhydride or a meso cyclic anhydride, comprising the step of: reacting a prochiral cyclic anhydride or a meso cyclic anhydride with a nucleophile in the presence of a catalyst; wherein said prochiral cyclic anhydride or meso cyclic anhydride comprises an internal plane of symmetry or point of symmetry or both; thereby producing a chiral, non-racemic compound; wherein said catalyst is a derivatized cinchona-alkaloid. Yet another aspect of the present invention relates to a method of kinetic resolution, comprising the step of: reacting a racemic cyclic anhydride with an alcohol in the presence of a derivatized cinchona-alkaloid catalyst.
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