发明授权
- 专利标题: Biomarker detection in circulating cells
- 专利标题(中): 循环细胞中生物标志物检测
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申请号: US10765773申请日: 2004-01-26
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公开(公告)号: US07537938B2公开(公告)日: 2009-05-26
- 发明人: Hrair Kirakossian , Thomas Klopack , Sharat Singh
- 申请人: Hrair Kirakossian , Thomas Klopack , Sharat Singh
- 申请人地址: US CA South San Francisco
- 专利权人: Monogram Biosciences, Inc.
- 当前专利权人: Monogram Biosciences, Inc.
- 当前专利权人地址: US CA South San Francisco
- 代理机构: Fenwick & West LLP
- 主分类号: G01N33/553
- IPC分类号: G01N33/553 ; G01N33/53
摘要:
A method is provided for detecting biomarkers in rare circulating cells by forming an enriched population of cells immunomagnetically followed by biomarker detection using binding compounds having releasable molecular tags. Preferably, biomarkers comprising one or more protein-protein complexes are detected in circulating cancer cells metastasized from a solid tumor. In the presence of biomarkers, the molecular tags of the binding compounds are released and separated from the assay mixture for detection and/or quantification.
公开/授权文献
- US20040157271A1 Biomarker detection in circulating cells 公开/授权日:2004-08-12