发明授权
- 专利标题： Comparative mycobacterial geneomics as a tool for identifying targets for the diagnosis, prophylaxis or treatment of mycobacterioses
- 专利标题（中）： 比较分枝杆菌基因组学作为确定分枝杆菌诊断，预防或治疗目标的工具
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申请号： US10468356申请日： 2002-02-22
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公开(公告)号： US07538206B2公开(公告)日： 2009-05-26
- 发明人: Stewart Cole
- 申请人： Stewart Cole
- 申请人地址： FR Paris
- 专利权人： Institut Pasteur
- 当前专利权人： Institut Pasteur
- 当前专利权人地址： FR Paris
- 代理机构： Finnegan, Henderson, Farabow, Garrett & Dunner L.L.P.
- 国际申请： PCT/IB02/01973 WO 20020222
- 国际公布： WO02/074903 WO 20020926
- 主分类号： C07H21/02
- IPC分类号： C07H21/02 ; C07H23/04 ; A61K39/04 ; C12N1/00
摘要：
The present invention is directed to a method of selection of purified nucleotidic sequences or polynucleotides encoding proteins or part of proteins carrying at least an essential function for the survival or the virulence of mycobacterium species by a comparative genomic analysis of the sequence of the genome of M. tuberculosis aligned on the genome sequence of M. leprae and M. tuberculosis and M. leprae marker polypeptides of nucleotides encoding the polypeptides, and methods for using the nucleotides and the encoded polypeptides are disclosed.
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