Aspects of a method and system for enhancement of power amplifier (PA) efficiency through controlled variation of gain in a power amplifier driver are presented. Aspects of the system may comprise an envelope detector that enables detection of an amplitude of an analog input signal. The envelope detector may enable computation of a first gain value based on the detection. A second gain value may be computed based on the first gain value. A PA may enable generation of an analog output signal based on the analog input signal, the first gain value and the second gain value.