A multiple-input multiple-output code division multiple access (MIMO-CDMA) wireless communication equipment has a transmitter and a receiver. The transmitter has an encoder for receiving and encoding a plurality of data, and sending the data to a quadrature phase-shift keying (QPSK) unit. The QPSK unit conducts QPSK modulating to an output of the encoder and sends it to a space-time block coding (STBC) unit or a space multiplexer to process space-time coding or space coding. A plurality of data frame generating modules generate a data frame respectively based on the output of the STBC unit, a plurality of preamble codes generated by a preamble code spreading unit, a pilot code and a cyclic prefix. The data frame is sent to the receiver via a plurality of transmitting antennas.