发明授权
- 专利标题： Antagonists of cxcr3-binding cxc chemokines
- 专利标题（中）： cxcr3结合cxc趋化因子的拮抗剂
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申请号： US10517726申请日： 2003-06-03
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公开(公告)号： US07541435B2公开(公告)日： 2009-06-02
- 发明人: Amanda Proudfoot , Marie Kosco-Vilbois
- 申请人： Amanda Proudfoot , Marie Kosco-Vilbois
- 申请人地址： CH Coinsins, Vaud
- 专利权人： Merck Serono SA
- 当前专利权人： Merck Serono SA
- 当前专利权人地址： CH Coinsins, Vaud
- 代理机构： Saliwanchik, Lloyd & Saliwanchik
- 优先权： EP02100697 20020612
- 国际申请： PCT/EP03/50211 WO 20030603
- 国际公布： WO03/106488 WO 20031224
- 主分类号： C07K14/00
- IPC分类号： C07K14/00 ; A61K45/00 ; A61K39/00 ; C07H21/04 ; C12P21/02
摘要：
Novel antagonists of CXCR3-binding CXC chemokines, and in particular of human CXCL11, can be obtained by generating mutants of such chemokines in which the binding to glycosaminoglycans (GAGs) is impaired due to non-conservative substitutions of amino acids involved in this interaction. Compounds prepared in accordance with the present invention can be used to block the activity of CXCR3-binding CXC chemokines on CXCR3-expressing cells, thereby providing therapeutic compositions for use in the treatment or prevention of diseases related to excessive activated T cells migration, such as graft rejection and autoimmune diseases, and of diseases needing an increase of vascularization, such as ischemic heart disease.
公开/授权文献
- US20060204498A1 Novel antagonists of cxcr3-binding cxc chemokines 公开/授权日：2006-09-14
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