Invention Grant
US07544512B2 Method of producing insulinotropic GLP-1 (7-36) polypeptide and/or GLP-1 analogs
有权
产生促胰岛素GLP-1（7-36）多肽和/或GLP-1类似物的方法
- Patent Title: Method of producing insulinotropic GLP-1 (7-36) polypeptide and/or GLP-1 analogs
- Patent Title (中): 产生促胰岛素GLP-1（7-36）多肽和/或GLP-1类似物的方法
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Application No.: US10761717Application Date: 2004-01-20
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Publication No.: US07544512B2Publication Date: 2009-06-09
- Inventor: Yukun Sun , Dengxi Wu , Aizhen Wu , Zhiyong Zhu , Gang Yu , Jiaxiang Zhou , Shaoling Zhao
- Applicant: Yukun Sun , Dengxi Wu , Aizhen Wu , Zhiyong Zhu , Gang Yu , Jiaxiang Zhou , Shaoling Zhao
- Applicant Address: CN
- Assignee: Shanhai Hua Yi Bio-Tech Lab
- Current Assignee: Shanhai Hua Yi Bio-Tech Lab
- Current Assignee Address: CN
- Agency: Perkins Coie LLP
- Agent Zhaohui Wang
- Priority: CN01126278 20010719
- Main IPC: A61K38/26
- IPC: A61K38/26 ; C12N15/16 ; A61K38/00
Abstract:
The present invention discloses a method of producing polypeptides, including insulinotropic GLP-1 (7-36) polypeptide and/or GLP-1 analogs, by ligating genes in a tandem way. Also disclosed are the recombinant polypeptides produced by such a method. Using the method of this invention, 1 to 32 copies of GLP-1 (7-36) and/or GLP-1 analog genes may be expressed in tandem and the desired polypeptide can be obtained after cleavage of a fusion protein and further processes of separation and purification thus making possible the production of recombinant polypeptides, including recombinant GLP-1 (7-36) and/or GLP-1 analogs on a large scale, at a significantly reduced production cost.
Public/Granted literature
- US20040146985A1 Method of producing insulinotropic GLP-1 (7-36) polypeptide and/or GLP-1 analogs Public/Granted day:2004-07-29
Information query
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