发明授权
- 专利标题： Inhibitors of Akt activity
- 专利标题（中）： Akt活性抑制剂
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申请号： US11659606申请日： 2005-08-19
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公开(公告)号： US07544677B2公开(公告)日： 2009-06-09
- 发明人: Mark T. Bilodeau , Nicholas D. P. Cosford , John C. Hartnett , Yiwei Li , Jun Liang , Peter J. Manley , Lou Anne Neilson , Tony Siu , Zhicai Wu
- 申请人： Mark T. Bilodeau , Nicholas D. P. Cosford , John C. Hartnett , Yiwei Li , Jun Liang , Peter J. Manley , Lou Anne Neilson , Tony Siu , Zhicai Wu
- 申请人地址： US NJ Rahway
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： US NJ Rahway
- 代理商 Matthew A. Leff; David A. Muthard
- 国际申请： PCT/US2005/029941 WO 20050819
- 国际公布： WO2006/036395 WO 20060406
- 主分类号： A61K31/541
- IPC分类号： A61K31/541 ; A61K31/5355 ; A61K31/519 ; C07D471/04 ; C07D519/00 ; A61P35/00
摘要：
The present invention is directed to compounds which contain substituted 5-deazapteridine moieties which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
公开/授权文献
- US20070254901A1 Inhibitors of Akt Activity 公开/授权日：2007-11-01