发明授权
- 专利标题： Docosahexaenoic acid producing strains of Yarrowia lipolytica
- 专利标题（中）： 二十二碳六烯酸生产的解脂耶氏酵母菌株
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申请号： US11264737申请日： 2005-11-01
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公开(公告)号： US07550286B2公开(公告)日： 2009-06-23
- 发明人: Howard Glenn Damude , Daniel Joseph Macool , Stephen K. Picataggio , James John Ragghianti , John E. Seip , Zhixiong Xue , Narendra S. Yadav , Hongxiang Zhang , Quinn Qun Zhu
- 申请人： Howard Glenn Damude , Daniel Joseph Macool , Stephen K. Picataggio , James John Ragghianti , John E. Seip , Zhixiong Xue , Narendra S. Yadav , Hongxiang Zhang , Quinn Qun Zhu
- 申请人地址： US DE Wilmington
- 专利权人： E. I. du Pont de Nemours and Company
- 当前专利权人： E. I. du Pont de Nemours and Company
- 当前专利权人地址： US DE Wilmington
- 主分类号： C12N1/16
- IPC分类号： C12N1/16 ; C12P7/64 ; C12N9/02 ; C07H21/04
摘要：
An engineered strain of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 5.6% docosahexaenoic acid acid (DHA, an w-3 polyunsaturated fatty acid) in the total oil fraction is described. This strain comprises various chimeric genes expressing heterologous desaturases, elongases and acyltransferases and optionally comprises various native desaturase and acyltransferase knockouts to enable synthesis and high accumulation of DHA. Production host cells are claimed, as are methods for producing DHA within said host cells.
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