发明授权
- 专利标题: Piperazinediones as oxytocin receptor antagonists
- 专利标题(中): 哌嗪类作为催产素受体拮抗剂
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申请号: US11630179申请日: 2005-06-21
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公开(公告)号: US07550462B2公开(公告)日: 2009-06-23
- 发明人: Alan David Borthwick , Deirdre Mary Bernadette Hickey , John Liddle , Andrew McMurtrie Mason
- 申请人: Alan David Borthwick , Deirdre Mary Bernadette Hickey , John Liddle , Andrew McMurtrie Mason
- 申请人地址: GB Greenford, Middlesex
- 专利权人: Glaxo Group Limited
- 当前专利权人: Glaxo Group Limited
- 当前专利权人地址: GB Greenford, Middlesex
- 代理商 Tony W. Peng; Wayne J. Dustman; Edward R. Gimmi
- 优先权: GB0414093.5 20040623
- 国际申请: PCT/EP2005/006760 WO 20050621
- 国际公布: WO2006/000399 WO 20060105
- 主分类号: A61K31/5377
- IPC分类号: A61K31/5377 ; C07D413/06 ; A61K31/496 ; C07D241/08
摘要:
Compounds of formula (I) wherein R1 is 2-indanyl, R2 is 1-methylpropyl, R3 is a group selected from 2,6-dimethyl-3-pyridyl or 4,6-dimethyl-3-pyridyl, R4 represents methyl and R5 represents hydrogen or methyl or, R4 and R5 together with the nitrogen atom to which they are attached represent morpholino and pharmaceutically acceptable derivatives thereof are described, as are processes for their preparation, pharmaceutical compositions containing them and their use in medicine, particularly their use as oxytocin antagonists.
公开/授权文献
- US20070254888A1 Piperazinediones as Oxytocin Receptor Antagonists 公开/授权日:2007-11-01
信息查询
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