发明授权
- 专利标题: Physiologically active substances
- 专利标题(中): 生理活性物质
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申请号: US11473201申请日: 2006-06-23
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公开(公告)号: US07550503B2公开(公告)日: 2009-06-23
- 发明人: Yoshihiko Kotake , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Mikie Kanada , Takashi Nakashima , Masahi Yoshida , Toshio Tsuchida
- 申请人: Yoshihiko Kotake , Jun Niijima , Yoshio Fukuda , Mitsuo Nagai , Regina Mikie Kanada , Takashi Nakashima , Masahi Yoshida , Toshio Tsuchida
- 申请人地址: JP Tokyo JP Tokyo
- 专利权人: Eisai R& D Management Co., Ltd.,Merican Corporation
- 当前专利权人: Eisai R& D Management Co., Ltd.,Merican Corporation
- 当前专利权人地址: JP Tokyo JP Tokyo
- 代理机构: Birch, Stewart, Kolasch & Birch, LLP
- 主分类号: A01N43/02
- IPC分类号: A01N43/02 ; A61K31/335 ; C07D313/00 ; C07D313/04
摘要:
The present invention relates to a compound represented by the formula (I): (wherein, R3, R6, R7 and R21 are the same as or different from one another and each represents a hydroxyl group etc.), a pharmacologically acceptable salt thereof or a hydrate of them. The compound (I) of the present invention suppresses angiogenesis, in particular, suppresses VEGF production in a hypoxic condition and is useful as a therapeutic agent for treating solid cancer.
公开/授权文献
- US20060241171A1 Novel physiologically active substances 公开/授权日:2006-10-26