发明授权
US07550619B2 Intermediates in the preparation of the antiviral agent [1S-(1α, 3α, 4β)]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxmethyl)-2-methylenecyclopentyl]-6H-purin-6-one
有权
制备抗病毒剂的中间体[1S-（1α，3α，4beta）] - 2-氨基-1,9-二氢-9- [4-羟基-3-（羟甲基）-2-亚甲基环戊基] 嘌呤-6-酮
![Intermediates in the preparation of the antiviral agent [1S-(1α, 3α, 4β)]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxmethyl)-2-methylenecyclopentyl]-6H-purin-6-one](/docs/US/2009-06-23/US07550619B2/abs.jpg.600x600.jpg)
- 专利标题： Intermediates in the preparation of the antiviral agent [1S-(1α, 3α, 4β)]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxmethyl)-2-methylenecyclopentyl]-6H-purin-6-one
- 专利标题（中）： 制备抗病毒剂的中间体[1S-（1α，3α，4beta）] - 2-氨基-1,9-二氢-9- [4-羟基-3-（羟甲基）-2-亚甲基环戊基] 嘌呤-6-酮
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申请号： US11311598申请日： 2005-12-19
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公开(公告)号： US07550619B2公开(公告)日： 2009-06-23
- 发明人: Yadagiri R. Pendri , Chung-Pin H. Chen , Jing Liang , Shaopeng Wang , Milan Stojanovic , Richard P. Polniaszek , John Thottathil , Dhileepkumar Krishnamurty
- 申请人： Yadagiri R. Pendri , Chung-Pin H. Chen , Jing Liang , Shaopeng Wang , Milan Stojanovic , Richard P. Polniaszek , John Thottathil , Dhileepkumar Krishnamurty
- 申请人地址： US NJ Princeton
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： US NJ Princeton
- 代理商 Jennifer Chin Chapman; James Epperson
- 主分类号： C07F7/04
- IPC分类号： C07F7/04 ; C07F7/08
![Intermediates in the preparation of the antiviral agent [1S-(1α, 3α, 4β)]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxmethyl)-2-methylenecyclopentyl]-6H-purin-6-one](/abs-image/US/2009/06/23/US07550619B2/abs.jpg.150x150.jpg)
摘要：
Intermediates useful in the preparation of the antiviral agent entecavir are disclosed. A resin adsorption process for the isolation and purification of entecavir is also disclosed. Various processes useful in the preparation of entecavir are also disclosed.
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