发明授权
- 专利标题： Benzamide inhibitors of the P2X7 receptor
- 专利标题（中）： P2X7受体的苯甲酰胺抑制剂
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申请号： US11673246申请日： 2007-02-09
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公开(公告)号： US07553972B2公开(公告)日： 2009-06-30
- 发明人: Mark A. Dombrowski , Allen J. Duplantier , Chakrapani Subramanyam
- 申请人： Mark A. Dombrowski , Allen J. Duplantier , Chakrapani Subramanyam
- 申请人地址： US NY New York
- 专利权人： Pfizer, Inc.
- 当前专利权人： Pfizer, Inc.
- 当前专利权人地址： US NY New York
- 代理商 Julie M. Lappin
- 主分类号： C07D211/70
- IPC分类号： C07D211/70 ; C07D241/02 ; C07D237/00
摘要：
The present invention provides benzamide inhibitors of the P2X7 receptor of the formula: wherein R1-R3 are as defined herein. The compounds of the invention are useful in the treatment of IL-1 mediated disorders, including, without limitation, inflammatory diseases such as osteoarthritis and rheumatoid arthritis; allergies, asthma, COPD, cancer, reperfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.
公开/授权文献
- US20070142329A1 Benzamide Inhibitors of the P2X7 Receptor 公开/授权日：2007-06-21
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