The present invention provides a driving circuit with protection function for driving a set of external electrode fluorescent lamps (EEFL). The drive circuit includes: a transformer connected to the set of EEFLs; a switching network connected to the transformer which delivers power to the transformer; a sensing circuit connected to the set of EEFLs which detects disconnection if one light source is disconnected; and a controller connected to the switching network which controls the switching network to reduce the total current supplied to the EEFLs which remain connected, if the sensing circuit detects that one EEFL is disconnected. Appropriate protection can therefore be implemented when the EEFL is disconnected on one end or both ends.