Invention Grant
- Patent Title: Quinazoline derivatives as kinase inhibitors
- Patent Title (中): 喹唑啉衍生物作为激酶抑制剂
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Application No.: US11210028Application Date: 2005-08-22
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Publication No.: US07560461B2Publication Date: 2009-07-14
- Inventor: Anjali Pandey , Robert M. Scarborough , Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shinichi Ide , Eiji Tsukuda , Junko Sasaki , Shoji Oda
- Applicant: Anjali Pandey , Robert M. Scarborough , Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shinichi Ide , Eiji Tsukuda , Junko Sasaki , Shoji Oda
- Applicant Address: US MA Cambridge JP Tokyo
- Assignee: Millennium Pharmaceuticals, Inc.,Kyowa Hakko Kogyo Co., Ltd.
- Current Assignee: Millennium Pharmaceuticals, Inc.,Kyowa Hakko Kogyo Co., Ltd.
- Current Assignee Address: US MA Cambridge JP Tokyo
- Agency: Townsend and Townsend and Crew LLP
- Main IPC: A61K31/497
- IPC: A61K31/497 ; A61K31/535 ; C07D413/12 ; C07D239/94
Abstract:
The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.
Public/Granted literature
- US20050288297A1 Quinazoline derivatives as kinase inhibitors Public/Granted day:2005-12-29
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