发明授权
US07560480B2 Alkyl-containing 5-acylindolinones, the preparation thereof and their use as medicaments
有权
含烷基的5-丙烯基吲哚酮，其制备及其作为药物的用途
- 专利标题： Alkyl-containing 5-acylindolinones, the preparation thereof and their use as medicaments
- 专利标题（中）： 含烷基的5-丙烯基吲哚酮，其制备及其作为药物的用途
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申请号： US11077399申请日： 2005-03-10
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公开(公告)号： US07560480B2公开(公告)日： 2009-07-14
- 发明人: Armin Heckel , Gerald Juergen Roth , Joerg Kley , Stefan Hoerer , Ingo Uphues
- 申请人： Armin Heckel , Gerald Juergen Roth , Joerg Kley , Stefan Hoerer , Ingo Uphues
- 申请人地址： DE Ingelheim
- 专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人地址： DE Ingelheim
- 代理商 Michael P. Morris; Edouard G. Lebel; David A. Dow
- 优先权： DE102004012068 20040312
- 主分类号： A61K31/404
- IPC分类号： A61K31/404 ; A61K31/4045 ; A61K31/4439 ; C07D401/12 ; C07D209/34
摘要：
The present invention relates to alkyl-containing 5-acylindolinones of general formula wherein R1 to R3 are defined herein, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on protein kinases, particularly an inhibiting effect on the activity of glycogen synthase kinase (GSK-3).
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